Long Non-Coding Ribonucleic Acid Disrupted in Renal Carcinoma 3 Inhibits Chemo-Resistance of Prostate Cancer via MicroRNA-24-3p/KIT Ligand Axis
نویسندگان
چکیده
Drug resistance is the leading cause of death in prostate cancer patients. Therefore, exploring mechanism underlying drug and identifying novel therapeutic targets are urgently needed. Long non-coding ribonucleic acid disrupted renal carcinoma 3 acts as a tumor suppressor gene several types. However, to date, no study has investigated biological function long cancer. Gene expression was detected by reverse transcription-quantitative polymerase chain reaction assay Western blot. Cell viability cell counting kit-8 apoptosis analyzed flow cytometry. The interactions between microRNA, microRNA messengerRNA were bioinformatics analysis confirmed dual-luciferase reporter assay. down-regulated drug-resistant tissues lines. Over overcome PC-3/R DU-145/R docetaxel down-regulating drugresistance related lung protein, P-glycoprotein multidrug resistance-associated protein. sponged microRNA-24-3p up-regulate KIT ligand. MicroRNA-24-3p/KIT ligand mediated effect noncoding overexpression on docetaxel-resistance cells. docetaxel-tolerated cells via microRNA-24-3p/KIT axis. Our revealed that potential target overcoming for
منابع مشابه
The Roles of Long non-coding RNAs (lncRNA) in Prostate Cancer
Background & Objective: Prostate cancer is a compound condition in which gene expression has altered. Several surveys have revealed that genetic components have been involved in prostate cancer progression. Findings proposed that they can modify a noteworthy portion of disposing of elements, which is associated to the developing prostate cancer in protein coding sequences. The purpose of this r...
متن کاملMicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...
متن کاملThe Role of Long Non-Coding RNAs in Ovarian Cancer
Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...
متن کاملClinical and in vitro Study of Novel Long Non-Coding RNA lncUSMycN in Breast Cancer Cancer
Background: Despite recent advances in diagnosis and treatment, breast cancer remains a leading cause of death in women worldwide. Long non-coding RNAs are a new class of RNA molecules that have been shown to participate in tumorigenesis. The aim of this study was to investigate the expression of lncUSMycN in tumor samples and to evaluate its potential role in the breast cancer cell line. Metho...
متن کاملmicrorna-205 inhibits renal cells apoptosis via targeting cmtm4
objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2022
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.503